Detailed view for LmjF.17.1430

Basic information

TDR Targets ID: 28139
Leishmania major, hypothetical protein, unknown function
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.2164 | Length (AA): 500 | MW (Da): 53928 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 12

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07690   Major Facilitator Superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
52 485 1pw4 (A) 15 449 16.00 0 0.79 1.24 -1.87
69 465 1ots (A) 35 436 13.00 0.000003 0.8 1.15 -2.47
63 487 1kpl (B) 31 462 17.00 0 0.99 0.9761 0.18
65 468 4u4v (A) 38 457 18.00 0 0.94 1.0371 -0.65
135 395 2qi9 (A) 92 322 23.00 0 0.59 0.3531 1.73
161 306 2nq2 (A) 16 168 32.00 0.3 0.08 0.1396 2.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127527)

Species Accession Gene Product
Brugia malayi Bm1_35820   Hypothetical transporter C09D4.1
Brugia malayi Bm1_16170   Major Facilitator Superfamily protein
Caenorhabditis elegans CELE_C09D4.1   Protein C09D4.1, isoform B
Caenorhabditis elegans CELE_B0416.5   Protein B0416.5, isoform B
Caenorhabditis elegans CELE_C42C1.8   Protein C42C1.8
Drosophila melanogaster Dmel_CG1358   CG1358 gene product from transcript CG1358-RD
Echinococcus granulosus EgrG_001130300   feline leukemia virus subgroup C
Echinococcus multilocularis EmuJ_001130300   feline leukemia virus subgroup C
Homo sapiens ENSG00000119686   feline leukemia virus subgroup C cellular receptor family, member 2
Homo sapiens ENSG00000169026   major facilitator superfamily domain containing 7
Homo sapiens ENSG00000162769   feline leukemia virus subgroup C cellular receptor 1
Leishmania braziliensis LbrM.03.0370   MFS transporter, putative
Leishmania braziliensis LbrM.17.1580   hypothetical protein, unknown function
Leishmania donovani LdBPK_171550.1   major facilitator superfamily, putative
Leishmania donovani LdBPK_030390.1   MFS transporter, putative
Leishmania infantum LinJ.03.0390   MFS transporter, putative
Leishmania infantum LinJ.17.1550   hypothetical protein, unknown function
Leishmania major LmjF.03.0410   MFS transporter, putative
Leishmania major LmjF.17.1430   hypothetical protein, unknown function
Leishmania mexicana LmxM.03.0410  
Leishmania mexicana LmxM.17.1430   hypothetical protein, unknown function
Loa Loa (eye worm) LOAG_02657   hypothetical protein
Loa Loa (eye worm) LOAG_03795   major facilitator superfamily transporter
Mus musculus ENSMUSG00000066595   major facilitator superfamily domain containing 7B
Mus musculus ENSMUSG00000029490   major facilitator superfamily domain containing 7A
Mus musculus ENSMUSG00000034258   major facilitator superfamily domain containing 7C
Schistosoma japonicum Sjp_0212580   ko:K08220 MFS transporter, FLVCR family, feline leukemia virus subgroup C, putative
Schistosoma japonicum Sjp_0090710   Major facilitator superfamily domain-containing protein 7-a, putative
Schistosoma mansoni Smp_090220   feline leukemia virus subgroup C receptor-related
Schistosoma mansoni Smp_143690   feline leukemia virus subgroup C receptor-related
Schmidtea mediterranea mk4.017148.00   Feline leukemia virus subgroup C receptor-related
Schmidtea mediterranea mk4.003761.03   Feline leukemia virus subgroup C receptor-related
Trypanosoma brucei gambiense Tbg972.10.4220   hypothetical protein, conserved
Trypanosoma brucei Tb11.v5.1021   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.10.3350   major facilitator superfamily, putative
Trypanosoma congolense TcIL3000_10_2790   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510309.20   MFS transporter, putative
Trypanosoma cruzi TcCLB.511421.210   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506669.4   MFS transporter, putative
Trypanosoma cruzi TcCLB.503505.20   MFS transporter, putative

Essentiality

LmjF.17.1430 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.3350 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.3350 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.3350 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.3350 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_B0416.5 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.17.1430 (Leishmania major), hypothetical protein, unknown function
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